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Other Name : Cassia angus-tifolia Folium Sennae,Cassia angustifolia Vahl
Specification : 4%,6%,8%,10%,20%,Sennosides A, Sennosides B
Appearance : Brown fine powder
Use Part : leaf
Mesh Size : 80 mesh
Test Method : UV,HPLC
The purgative action of senna leaf is primarily due to the presence of organic anthraquinones in the form of various glycosides, including hydroxyanthracene, dianthrone, and naphthalene glycosides. Senna also contains a group of glycosides referred to as simply sennosides. These compounds stimulate the smooth muscles that transport digested food through the intestines, thereby contributing to enhanced stool volume and an increase in peristaltic contractions to move it out of the colon. These actions stem from two events: An increased production of acetate, proprionate and butyric short chain fatty acids to promote fermentation, or digestion; and the successful conversion of glycosides into a powerful purgative agent known as rheinanthrone glucoside.
Senna is a potent laxative. Its cathartic effects can be obtained from a tea prepared from one or two teaspoonfuls of dried leaves. Senna's use in treating constipation is well documented. It is one of the most popular laxatives, especially in the elderly and for long-term laxative treatment.
The quality of the starting material is an essential prerequisite,since it may affect all the subsequent phases. Hence GMPs are applied already from these early steps to guarantee the characteristics of the final product. At this stage,there are a number of measures we employ:
√ supplier inspection and qualification
√ area selection
√ control of:
– harvesting period and harvesting method
– drying conditions
√ botanical identification of the plant and part of the plant
√ quarantine of the biomass under monitored conditions
√ microbiological analysis
√ chemical analysis
√ control of contaminants, including:
– heavy metals
Only after all of these controls will the raw material be released for further processing or rejected due to non conformance with our strict requirements.
Cathartic effect: senna infusion contains anthraquinone derivatives, its cathartic effect and irritation more than other laxatives.
Antibacterial inhibition: senna extract alcohol resistant variety of bacteria such as staphylococcus, diphtheria bacillus, typhoid bacillus, paratyphoid bacillus, and escherichia coli, the water extract useful only for Salmonella typhi.
Hemostasis: senna powder can increase platelet and fibrinogen, reduced clotting time, recalcification time, prothrombin time and blood clot contraction time, help to stop the bleeding
Muscle relaxation: senna can block acetylcholine at the motor nerve terminals and skeletal joints, so that muscle relaxation.
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